JZP 430

Key Product Details

Product Description

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC₅₀ = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Product Specifications for JZP 430

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JZP 430

The following data is based on the product molecular weight 354.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.64 mL	28.21 mL	56.42 mL
2.5 mM	1.13 mL	5.64 mL	11.28 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
25 mM	0.11 mL	0.56 mL	1.13 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Patel Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 2015 PMID: 25504894

Product Documents for JZP 430