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Kaempferol | CAS No. 520-18-3 | Other Ion Pump/Transporter Activators
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Description: Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Alternative Names: Kempferol

Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

Activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine. Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC50 = 21.5 μM). Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA). Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure. Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
    Cho et al.
    Cancer Res., 2007;67:8104
  2. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.
    Montero et al.
    Biochem.J., 2004;384:19
  3. Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells.
    Suh et al.
    Biol.Pharm.Bull., 2009;32:746
  4. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells.
    Kang et al.
    Eur.J.Pharmacol., 2009;611:17
  5. Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation.
    Vay et al.
    J.Physiol., 2009;580:39
  6. TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol.
    Byun et al.
    Bone, 2012;50:364

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Citation for Kaempferol

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