Naturally occurring flavonoid found in Gingko biloba
and red wines that activates the mitochondrial Ca2+
= 7 μ
M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro
. Also blocks EGF-induced histone H3Ser10
phosphorylation in mouse epidermal JB6 C141 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells.
Suh et al.
Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells.
Kang et al.
Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.
Montero et al.
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
Cho et al.
Cancer Res., 2007;67:8104
Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation.
Vay et al.
The citations listed below are publications that use Tocris products. Selected citations for Kaempferol include:
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