Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Biological ActivityActivates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
Cho et al.
Cancer Res., 2007;67:8104
Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.
Montero et al.
Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells.
Suh et al.
Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells.
Kang et al.
Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation.
Vay et al.
TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol.
Byun et al.
Citation for Kaempferol
The citations listed below are publications that use Tocris products. Selected citations for Kaempferol include:
1 Citation: Showing 1 - 1
Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.
Authors: Tran Et al.
ACS Chem Biol 2014;9:2796
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Islets were maintained in CMRL medium supplemented with 10% FBS and kaempferol