Kaempferol

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3603/50
Kaempferol | CAS No. 520-18-3 | Other Ion Pump/Transporter Activators
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Description: Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Alternative Names: Kempferol

Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Technical Data

M.Wt:
286.24
Formula:
C15H10O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
520-18-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
    Cho et al.
    Cancer Res., 2007;67:8104
  2. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.
    Montero et al.
    Biochem.J., 2004;384:19
  3. Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells.
    Suh et al.
    Biol.Pharm.Bull., 2009;32:746
  4. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells.
    Kang et al.
    Eur.J.Pharmacol., 2009;611:17
  5. Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation.
    Vay et al.
    J.Physiol., 2009;580:39

Product Datasheets

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Citation for Kaempferol

The citations listed below are publications that use Tocris products. Selected citations for Kaempferol include:

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treat kaemferol in vitro system
By Anonymous on 11/03/2019
Species: Mouse

Islets were maintained in CMRL medium supplemented with 10% FBS and kaempferol

PMID: 25279668

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