KC7F2

Catalog # Availability Size / Price Qty
4324/10
4324/50
Cat.No. 4324 - KC7F2 | C16H16Cl4N2O4S4 | CAS No. 927822-86-4
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Description: HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

Product Details
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Biological Activity

Inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data

Formula:
C16H16Cl4N2O4S4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
927822-86-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Identification of a novel small molecule HIF-1α translation inhibitor.
    Narita et al.
    Clin.Cancer Res., 2009;15:6128
  2. Inhibiting the hypoxia response for cancer therapy: the new kid on the block.
    Koh et al.
    Clin.Cancer Res., 2009;15:5945

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