KC7F2

Key Product Details

Product Description

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Product Specifications for KC7F2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KC7F2

The following data is based on the product molecular weight 570.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.75 mL	8.77 mL	17.53 mL
5 mM	0.35 mL	1.75 mL	3.51 mL
10 mM	0.18 mL	0.88 mL	1.75 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Koh Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 2009 PMID: 19789327
• Narita Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 2009 PMID: 19789328

Product Documents for KC7F2