Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Biological ActivityInhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Identification of a novel small molecule HIF-1α translation inhibitor.
Narita et al.
Clin.Cancer Res., 2009;15:6128
Inhibiting the hypoxia response for cancer therapy: the new kid on the block.
Koh et al.
Clin.Cancer Res., 2009;15:5945
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for KC7F2
There are currently no reviews for this product. Be the first to review KC7F2 and earn rewards!
Have you used KC7F2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image