Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Biological ActivityKC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibiting the hypoxia response for cancer therapy: the new kid on the block.
Koh et al.
Clin.Cancer Res., 2009;15:5945
Identification of a novel small molecule HIF-1α translation inhibitor.
Narita et al.
Clin.Cancer Res., 2009;15:6128
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