Inhibitor of HIF-1α
. Thought to act via down-regulation of HIF-1α
protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α
accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.
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All Tocris products are intended for laboratory research use only.
Inhibiting the hypoxia response for cancer therapy: the new kid on the block.
Koh et al.
Clin.Cancer Res., 2009;15:5945
Identification of a novel small molecule HIF-1α translation inhibitor.
Narita et al.
Clin.Cancer Res., 2009;15:6128