Ketoconazole

Key Product Details

Product Description

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Product Specifications for Ketoconazole

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ketoconazole

The following data is based on the product molecular weight 531.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.51 mL	12.54 mL	25.09 mL
3.75 mM	0.50 mL	2.51 mL	5.02 mL
7.5 mM	0.25 mL	1.25 mL	2.51 mL
37.5 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
• Hubler Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 2018 PMID: 30046109
• Dumaine Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 1998 PMID: 9694927
• Kuhn-Velten Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 1992 PMID: 1472102
• Ayub and Levell Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 1989 PMID: 2724954

Product Documents for Ketoconazole