Catalog Number: 1103
Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine
Biological Activity
Antifungal agent; potent inhibitor of cytochrome P450c17.
Technical Data
  • M.Wt:
    531.44
  • Formula:
    C26H28Cl2N4O4
  • Solubility:
    Soluble to 50 mM in ethanol and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    65277-42-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole.
    Ayub and Levell
    J.Steroid Biochem., 1989;32:515
  3. Blockade of HERG and Kv1.5 by ketoconazole.
    Dumaine et al.
    J.Pharmacol.Exp.Ther., 1998;286:727
  4. Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate.
    Kuhn-Velten et al.
    Biochem.Pharmacol., 1992;44:2371

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