KG 5

Catalog # Availability Size / Price Qty
5260/10
5260/50
Cat.No. 5260 - KG 5 | C20H16F3N7OS | CAS No. 877874-85-6
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Description: PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Chemical Name: 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine

Purity: ≥98%

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Biological Activity

PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.

Technical Data

M.Wt:
459.45
Formula:
C20H16F3N7OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
877874-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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