KH-4-43

Key Product Details

Product Description

KH-4-43 is a selective CUL4 inhibitor (Kd = 83 nM). KH-4-43 inhibits the ubiquitination of CK1α by CRL4CRBN in vitro. Treatment of cells with KH-4-43 causes accumulation of the E3 CRL4 substrate CDT1. KH-4-43 suppresses the growth of human tumor xenografts in mice.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Product Specifications for KH-4-43

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for KH-4-43

The following data is based on the product molecular weight 422.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.73 mL	23.66 mL	47.31 mL
2.5 mM	0.95 mL	4.73 mL	9.46 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
25 mM	0.09 mL	0.47 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wu Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential. Proc.Natl.Acad.Sci.U.S.A. 2021 PMID: 33602808

Product Documents for KH-4-43