KH 7

Catalog # Availability Size / Price Qty
KH 7 | CAS No. 330676-02-3 | Adenylyl Cyclase Inhibitors
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Description: Selective soluble adenylyl cyclase inhibitor

Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

Purity: ≥99%

Product Details
Citations (9)

Biological Activity

KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
    Kumar et al.
    J.Biol.Chem., 2009;284:14760
  2. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
    Stessin et al.
    J.Biol.Chem., 2006;281:17253
  3. The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
    Hess et al.
    Develop.Cell, 2005;9:249

Product Datasheets

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Citations for KH 7

The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:

9 Citations: Showing 1 - 9


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