Selective soluble adenylyl cyclase (sAC) inhibitor (IC50
= 3 - 10 μ
M in vivo
). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro
and in whole cells at concentrations up to 300 μ
M. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μ
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Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
Kumar et al.
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
Stessin et al.
The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
Hess et al.
The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:
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