hh KH 7 (CAS 330676-02-3): R&D Systems
Catalog Number: 3834
Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Biological Activity
Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
Technical Data
  • M.Wt:
    419.3
  • Formula:
    C17H15BrN4O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    330676-02-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
    Kumar et al.
    J.Biol.Chem., 2009;284:14760
  2. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
    Stessin et al.
    J.Biol.Chem., 2006;281:17253
  3. The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
    Hess et al.
    Develop.Cell, 2005;9:249
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:

3 Citations: Showing 1 - 3
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  1. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
    Authors: Chen Et al.
    Mediators Inflamm 2013;9:2033
  2. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov 2013;3:1364
  3. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123

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