KH 7

  ( 6 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3834
Chemical Name:(±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Product Details
Citations (6)
Reviews
Biological Activity
Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
Technical Data
  • M.Wt:
    419.3
  • Formula:
    C17H15BrN4O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    330676-02-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:

6 Citations: Showing 1 - 6
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  1. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
    Authors: Inda Et al.
    Sci Rep  2017;7:1944
  2. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
    Authors: Inda Et al.
    J Cell Biol  2016;214:181
  3. Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.
    Authors: Shahidullah Et al.
    Invest Ophthalmol Vis Sci  2014;55:187
  4. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
    Authors: Chen Et al.
    Mediators Inflamm  2013;9:2033
  5. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov  2013;3:1364
  6. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123

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Average Rating: 5 (Based on 1 review)

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  Rat Hyun Choi 01/31/2018
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Other Experimental Details pretreat KH7 at least 30 min before treatment

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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