Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Biological ActivityKH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
Kumar et al.
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
Stessin et al.
The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
Hess et al.
Citations for KH 7
The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:
9 Citations: Showing 1 - 9
Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
Authors: Schnúr Et al.
Sci Rep 2019;9:12706
An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes.
Authors: Ishii Et al.
Anal Biochem 2019;577:52
Reconsideration of the evaluation criteria for bull ejaculated sperm motility in the context of rotation.
Authors: Yamada Et al.
J Reprod Dev 2018;64:377
cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
Authors: Inda Et al.
Sci Rep 2017;7:1944
Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
Authors: Inda Et al.
J Cell Biol 2016;214:181
Nonpigmented ciliary epithelial cells respond to acetazol. by a soluble adenylyl cyclase mechanism.
Authors: Shahidullah Et al.
Invest Ophthalmol Vis Sci 2014;55:187
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
Authors: Chen Et al.
Mediators Inflamm 2013;9:2033
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Authors: Jahchan Et al.
Cancer Discov 2013;3:1364
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for KH 7
Average Rating: 5 (Based on 1 Review)
Have you used KH 7?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Used KH7 to block soluble adenylyl cyclase which is sensitive to bicarbonate. Used at 20uM in rat brain slice.