Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Biological ActivitySelective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
Kumar et al.
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
Stessin et al.
The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
Hess et al.
Citations for KH 7
The citations listed below are publications that use Tocris products. Selected citations for KH 7 include:
9 Citations: Showing 1 - 9
Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.
Authors: Schnúr Et al.
Sci Rep 2019;9:12706
An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes.
Authors: Ishii Et al.
Anal Biochem 2019;577:52
Reconsideration of the evaluation criteria for bull ejaculated sperm motility in the context of rotation.
Authors: Yamada Et al.
J Reprod Dev 2018;64:377
cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
Authors: Inda Et al.
Sci Rep 2017;7:1944
Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
Authors: Inda Et al.
J Cell Biol 2016;214:181
Nonpigmented ciliary epithelial cells respond to acetazol. by a soluble adenylyl cyclase mechanism.
Authors: Shahidullah Et al.
Invest Ophthalmol Vis Sci 2014;55:187
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
Authors: Chen Et al.
Mediators Inflamm 2013;9:2033
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Authors: Jahchan Et al.
Cancer Discov 2013;3:1364
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
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Used KH7 to block soluble adenylyl cyclase which is sensitive to bicarbonate. Used at 20uM in rat brain slice.