Ki 16425
Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Purity: ≥98%
Biological Activity
Ki 16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Ohta et al.
Mol.Pharmacol., 2003;64:994 -
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Yamada et al.
J.Biol.Chem., 2004;279:6595 -
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Yu et al.
Cell, 2012;150:780
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Ki 16425
The citations listed below are publications that use Tocris products. Selected citations for Ki 16425 include:
1 Citation: Showing 1 - 1
-
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
Authors: Evseenko Et al.
PLoS One 2013;8:e63718
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for Ki 16425
Average Rating: 5 (Based on 1 Review)
Have you used Ki 16425?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
MG-63 cells were pre-incubated with 10 µM Ki 16425 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. Ki 16425 inhibited COX-2 induction by LPA.
