Ki 16425

  ( 1 citations )    
Product Datasheet
Catalog Number:5056
Chemical Name:3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
Technical Data
  • M.Wt:
    474.96
  • Formula:
    C23H23ClN2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    355025-24-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ki 16425 include:

1 Citations: Showing 1 - 1

  1. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One  2013;8:e63718

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