Ki 16425

Catalog # Availability Size / Price Qty
5056/25
5056/5
Lysophosphatidic Acid (LPA) Receptor Antagonists Small Molecule
1 Image
Description: LPA1 and LPA3 receptor antagonist

Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Technical Data

M.Wt:
474.96
Formula:
C23H23ClN2O5S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
355025-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Ki 16425

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Ki 16425 inhibits LPA-mediated COX-2 activation
By Anonymous on 12/13/2018
Species: Human

MG-63 cells were pre-incubated with 10 µM Ki 16425 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. Ki 16425 inhibited COX-2 induction by LPA.


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