Catalog Number: 5056
Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Biological Activity
Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
Technical Data
  • M.Wt:
    474.96
  • Formula:
    C23H23ClN2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    355025-24-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
    Yu et al.
    Cell, 2012;150:780
  2. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
    Ohta et al.
    Mol.Pharmacol., 2003;64:994
  3. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
    Yamada et al.
    J.Biol.Chem., 2004;279:6595
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ki 16425 include:

1 Citations: Showing 1 - 1

  1. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One 2013;8:e63718

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