Antagonist of the lysophosphatidic acid receptors LPA1
values are 0.25 and 0.36 μ
M respectively, in a GTPγ
S binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Yu et al.
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Ohta et al.
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Yamada et al.
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