Ki 16425

Tocris Bioscience | Catalog # 5056

LPA1 and LPA3 receptor antagonist
Tocris Bioscience
Discontinued Product
5056 has been discontinued. View all Lysophosphatidic Acid (LPA) Receptor Antagonists products.

Key Product Details

Description

LPA1 and LPA3 receptor antagonist
View all Lysophosphatidic Acid (LPA) Receptor Antagonists »

Product Description

Ki 16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Product Specifications for Ki 16425

Molecular Weight

474.96

Formula

C23H23ClN2O5S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid

CAS Number

355025-24-0

PubChem ID

10367662

InChI Key

LLIFMNUXGDHTRO-UHFFFAOYSA-N

SMILES

CC1=NOC(C2=CC=C(CSCCC(O)=O)C=C2)=C1NC(OC(C3=CC=CC=C3Cl)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.5 100
1eq. NaOH 9.5 20

Preparing Stock Solutions for Ki 16425

The following data is based on the product molecular weight 474.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Ki 16425

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ki 16425

For research use only

Customer Reviews for Ki 16425 (1)

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  • Ki 16425 inhibits LPA-mediated COX-2 activation
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    MG-63 cells were pre-incubated with 10 µM Ki 16425 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. Ki 16425 inhibited COX-2 induction by LPA.
    Ki 16425 5056

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