Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Biological ActivityAntagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Ohta et al.
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Yamada et al.
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Yu et al.
Citation for Ki 16425
The citations listed below are publications that use Tocris products. Selected citations for Ki 16425 include:
1 Citation: Showing 1 - 1
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
Authors: Evseenko Et al.
PLoS One 2013;8:e63718
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Ki 16425
There are currently no reviews for this product. Be the first to review Ki 16425 and earn rewards!
Have you used Ki 16425?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image