Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
Biological ActivityInhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.
Kubota et al.
The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.
Ohno et al.
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
Ohno et al.
Mol.Cancer Ther., 2006;5:2634
Citation for Ki 20227
The citations listed below are publications that use Tocris products. Selected citations for Ki 20227 include:
1 Citation: Showing 1 - 1
Macrophages form functional vascular mimicry channels in vivo.
Authors: Barnett Et al.
Sci Rep 2016;6:36659
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