Ki 20227

   
Product Datasheet
Catalog Number:4481
Chemical Name:N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
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Biological Activity
Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.
Technical Data
  • M.Wt:
    480.54
  • Formula:
    C24H24N4O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at +4°C
  • CAS No:
    623142-96-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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