Catalog Number: 4481
Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
Biological Activity
Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.
Technical Data
  • M.Wt:
    480.54
  • Formula:
    C24H24N4O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    623142-96-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.
    Kubota et al.
    J.Exp.Med., 2009;206:1089
  2. The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.
    Ohno et al.
    Eur.J.Immunol., 2007;38:283
  3. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
    Ohno et al.
    Mol.Cancer Ther., 2006;5:2634

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