Ki 20227

Catalog # Availability Size / Price Qty
4481/10
4481/50
Ki 20227 | CAS No. 623142-96-1 | Additional RTK Inhibitors
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Description: c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

Technical Data

M.Wt:
480.54
Formula:
C24H24N4O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
623142-96-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Ki 20227

The citations listed below are publications that use Tocris products. Selected citations for Ki 20227 include:

1 Citation: Showing 1 - 1

  1. Macrophages form functional vascular mimicry channels in vivo.
    Authors: Barnett Et al.
    Sci Rep  2016;6:36659

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