KISS1 305
Tocris Bioscience | Catalog # 7490
Product Description
KISS1 305 is a potent Kisspeptin1 receptor agonist (EC50 = 10 nM). It binds with high affinity to rat and human KISS1 receptors with Ki values of 0.14 nM and 0.11 nM respectively. In vivo, chronic administration of KISS1 305 reduces plasma testosterone and genital organ weights in male rats.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the KISS1-305 probe summary on the SGC website.External Portal Information
Chemicalprobes.orgis a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KISS1-305 is reviewed on the chemical probes website.
Product Specifications for KISS1 305
Molecular Weight
Formula
Storage
Purity
CAS Number
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Müller Donated chemical probes for open science. Elife 2018 PMID: 29676732
- Asami Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity. J.Med.Chem. 2013 PMID: 24047141
- Asami Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity. J.Med.Chem. 2014 PMID: 24918545
- Matsui Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats. Endocrinology 2012 PMID: 23027808
Product Documents for KISS1 305
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for KISS1 305
For research use only
Related Research Areas
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