Kv7.4 Antibody

Novus Biologicals | Catalog # NB100-93448

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Kv7.4 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DKGPSDAEVVDE corresponding to internal region according to NP_004691.2, NP_751895.1.

Epitope

C-DKGPSDAEVVDE

Specificity

This antibody is expected to recognise both reported isoforms (NP_004691.2; NP_751895.1); may cross-react in Mouse;

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Kv7.4 Antibody

Western Blot: Kv7.4 Antibody [NB100-93448]

Western Blot: Kv7.4 Antibody [NB100-93448]

Western Blot: Kv7.4 Antibody [NB100-93448] - Analysis of Kv7.4 in Cerebellum lysate (35ug protein in RIPA buffer) using NB100-93448 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Kv7.4 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 70 kDa band observed in human brain (cerebellum) lysates (calculated MW of 71.2 kDa band according to NP_751895.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Kv7.4

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

Potassium voltage-gated channel subfamily KQT member 4

Alternate Names

KCNQ4, KQT-like 4

Entrez Gene IDs

9132 (Human)

Gene Symbol

KCNQ4

UniProt

NP_004691.2 (Human)

Additional Kv7.4 Products

Product Documents for Kv7.4 Antibody

Certificate of Analysis

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Product Specific Notices for Kv7.4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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