KW 3902

Catalog # Availability Size / Price Qty
4167/10
4167/50
Adenosine A1 Receptor Antagonists Small Molecule
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Description: Selective A1 antagonist
Alternative Names: Rolofylline

Chemical Name: 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione

Purity: ≥99%

Product Details
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Reviews (1)

Biological Activity

Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

Technical Data

M.Wt:
356.46
Formula:
C20H28N4O2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
136199-02-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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systemic administration of KW3902
By Ariel Vitenzon on 01/05/2018
Species: Mouse

We injected this drug at 1 mg/Kg and 2 mg/Kg systemically (IP) into transgenic mice and monitored the effect on motor behavior. The drug efficiently induced motor symptoms in the transgenic mice at these concentrations.


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