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KW 3902

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KW 3902 | CAS No. 136199-02-5 | Adenosine A1 Receptor Antagonists
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Description: Selective A1 antagonist
Alternative Names: Rolofylline

Chemical Name: 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

Technical Data

M.Wt:
356.46
Formula:
C20H28N4O2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
136199-02-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for KW 3902

The citations listed below are publications that use Tocris products. Selected citations for KW 3902 include:

1 Citation: Showing 1 - 1

  1. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
    Authors: Cheng Et al.
    Structure  2017;25:1275

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VersaClone cDNA Plasmids

Mouse Adenosine A1R (NP_000665) VersaClone cDNA

RDC2041

Human Adenosine A1R (NP_000665) VersaClone cDNA

RDC0213

Reviews for KW 3902

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systemic administration of KW3902
By Ariel Vitenzon on 01/05/2018
Application: Species: Mouse

We injected this drug at 1 mg/Kg and 2 mg/Kg systemically (IP) into transgenic mice and monitored the effect on motor behavior. The drug efficiently induced motor symptoms in the transgenic mice at these concentrations.

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