KW 3902
Chemical Name: 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
Purity: ≥99%
Biological Activity
Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
Shimada et al.
J.Med.Chem., 1992;35:924 -
KW-3902, a selective high affinity antagonist for adenosine A1 receptors.
Nonaka et al.
Br.J.Pharmacol., 1996;117:1645 -
Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction.
Nishiyama et al.
J.Pharmacol.Exp.Ther., 1999;291:988
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We injected this drug at 1 mg/Kg and 2 mg/Kg systemically (IP) into transgenic mice and monitored the effect on motor behavior. The drug efficiently induced motor symptoms in the transgenic mice at these concentrations.
