KYT 0353

Catalog # Availability Size / Price Qty
5026/5
KYT 0353 | CAS No. 1597402-27-1 | Other Ion Pump/Transporter Inhibitors
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Description: Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo
Alternative Names: JPH 203

Chemical Name: O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride

Purity: ≥96%

Product Details
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Biological Activity

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells). Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM). Displays ~500-fold selectivity for LAT1 over LAT2. Reduces cell viability and induces apoptosis in YD-38 oral cancer cells. Arrests growth in several tumor cell lines. Exhibits growth inhibitory effects on HT-29 cells in vivo.

Technical Data

M.Wt:
545.24
Formula:
C23H19Cl2N3O4.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥96%
Storage:
Store at -20°C
CAS No:
1597402-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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