L-152,804

Key Product Details

Product Description

L-152,804 is a potent, selective non-peptide neuropeptide Y Y₅ receptor antagonist (K_i = 26 nM for hY₅). Displays > 300-fold selectivity over hY₁, hY₂, and hY₄ receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.

Product Specifications for L-152,804

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-152,804

The following data is based on the product molecular weight 366.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.64 mL	27.29 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.36 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

• Mashiko A pair-feeding study reveals that a Y₅ antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol.Pharmacol. 2007 PMID: 17105869
• Schroeder The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol 2005 PMID: 16377459
• Kanatani L-152,804: orally active and selective neuropeptide Y Y₅ receptor antagonist. Biochem.Biophys.Res.Commun. 2000 PMID: 10872822

Product Documents for L-152,804