Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Biological ActivityL-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
Kees et al.
A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260.
Lotti and Chang
Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Chung et al.
Brain Res., 2009;1282:10
Citation for L-365,260
The citations listed below are publications that use Tocris products. Selected citations for L-365,260 include:
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