Catalog Number: 2767
Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Biological Activity
Selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.
Technical Data
  • M.Wt:
    398.46
  • Formula:
    C24H22N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    118101-09-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cholecystokinin action on layer 6b neurons in somatosensory cortex.
    Chung et al.
    Brain Res., 2009;1282:10
  2. Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
    Kees et al.
    J.Med.Chem., 1989;32:13
  3. A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260.
    Lotti and Chang
    Eur.J.Pharmacol., 1989;162:273
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-365,260 include:

1 Citations: Showing 1 - 1

  1. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
    Authors: Wu Et al.
    Toxicol Sci 2014;138:278

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