L-368,899 hydrochloride

Tocris Bioscience | Catalog # 2641

Potent, non-peptide oxytocin receptor antagonist
Tocris Bioscience

Key Product Details

Description

Potent, non-peptide oxytocin receptor antagonist
View all Oxytocin Receptor Antagonists »

Product Description

L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.

Product Specifications for L-368,899 hydrochloride

Molecular Weight

627.68

Formula

C26H42N4O5S2.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide dihydrochloride

PubChem ID

90488775

InChI Key

WJPIJZWOCNBGTR-HILSUTFGSA-N

SMILES

CC(C=CC=C1)=C1N2CCN(S(C[C@@]34CC[C@@H](C4(C)C)C[C@@H]3NC([C@@H](N)CCS(C)(=O)=O)=O)(=O)=O)CC2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 59.12 100
DMSO 59.12 100

Preparing Stock Solutions for L-368,899 hydrochloride

The following data is based on the product molecular weight 627.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.97 mL 15.93 mL
5 mM 0.32 mL 1.59 mL 3.19 mL
10 mM 0.16 mL 0.80 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

Product Documents for L-368,899 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-368,899 hydrochloride

For research use only

Citations for L-368,899 hydrochloride

Customer Reviews for L-368,899 hydrochloride (1)

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  • Works as expected.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/26/2020
    We performed ex-vivo slice physiology, and bath applied L-368,899 hydrochloride.
    L-368,899 hydrochloride 2641

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