L-368,899 hydrochloride

Catalog # Availability Size / Price Qty
2641/1
2641/10

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L-368,899 hydrochloride | Oxytocin Receptor Antagonists
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Description: Potent, non-peptide oxytocin receptor antagonist

Chemical Name: (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide dihydrochloride

Purity: ≥97%

Product Details
Citations (4)
Reviews

Biological Activity

L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.

Technical Data

M.Wt:
627.68
Formula:
C26H42N4O5S2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-368,899 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for L-368,899 hydrochloride include:

4 Citations: Showing 1 - 4

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