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L-689,560 | CAS No. 139051-78-8 | NMDA Receptor Antagonists
1 Image
Description: Highly potent NMDA antagonist

Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline

Purity: ≥99%

Product Details
Citations (9)

Biological Activity

L-689,560 is a very potent antagonist at the glycine-NMDA site.

Technical Data

Soluble to 25 mM in DMSO and to 100 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor.
    Leeson et al.
    J.Med.Chem., 1992;35:1954
  3. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
    TiPS, 2000;21:149
  4. trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists.
    Leeson et al.
    Med.Chem.Res., 1991;1:64

Product Datasheets

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Citations for L-689,560

The citations listed below are publications that use Tocris products. Selected citations for L-689,560 include:

9 Citations: Showing 1 - 9


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