Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Biological ActivityL-689,560 is a very potent antagonist at the glycine-NMDA site.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor.
Leeson et al.
Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists.
Leeson et al.
Citations for L-689,560
The citations listed below are publications that use Tocris products. Selected citations for L-689,560 include:
9 Citations: Showing 1 - 9
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Authors: Wall Et al.
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Authors: Park Et al.
J Neurosci 2016;36:622
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Authors: Dennis Et al.
Mol Brain 2016;26:414
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
Authors: Fang Et al.
Toxicol Lett 2015;8:75
Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation.
Authors: Ng Et al.
Mol Brain 2014;7:60
The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility.
Authors: Eales Et al.
Nat Commun 2014;5:4701
Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
Authors: Potier Et al.
Front Aging Neurosci 2010;2:1
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Authors: Dargan Et al.
D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.
Authors: Rouaud and Billard
Br J Pharmacol 2003;140:1051
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for L-689,560
There are currently no reviews for this product. Be the first to review L-689,560 and earn rewards!
Have you used L-689,560?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image