Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Biological ActivityL-741,626 is a potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonism of the effects of (+)-PD 128907 on midbrain DA neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
Bowery et al.
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human DA D4 receptor.
Kulagowski et al.
S33084, a novel, potent, selective, and competitive antagonist at DA D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
Millan et al.
Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect
Pillai et al.
Citations for L-741,626
The citations listed below are publications that use Tocris products. Selected citations for L-741,626 include:
10 Citations: Showing 1 - 10
Functional roles of ST8SIA3-mediated sialylation of striatal DA D2 and adenosine A2A receptors.
Authors: Lin Et al.
Transl Psychiatry 2019;9:209
GPR139 and DA D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
Authors: Wang Et al.
Front Neurosci 2019;13:281
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
Biased OXTergic Modulation of Midbrain DA Systems.
Authors: Xiao Et al.
Examining the Effects of Sodium Ions on the Binding of Antagonists to DA D 2 and D 3 Receptors
Authors: Newton Et al.
PLoS One 2016;11:e0158808
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
J Neurosci 2015;11:2057
DA receptors in human embryonic stem cell neurodifferentiation.
Authors: Belinsky Et al.
Stem Cells Dev 2013;22:1522
Leptin reduces food intake via a DA D2 receptor-dependent mechanism.
Authors: Billes Et al.
Mol Metab 2012;1:86
Olfactory modulation by DA in the context of aversive learning.
Authors: Dacks Et al.
J Neurophysiol 2012;108:539
Inhibition of ATP-sensitive potassium channels by halope.
Authors: Yang Et al.
Br J Pharmacol 2004;143:960
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