L-741,626

  ( 4 citations )    
Product Datasheet
Catalog Number:1003
Chemical Name:3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
A potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    340.85
  • Formula:
    C20H21ClN2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    81226-60-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-741,626 include:

4 Citations: Showing 1 - 4
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  1. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors
    Authors: Newton Et al.
    PLoS One  2016;11:e0158808
  2. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    J Neurosci  2015;11:2057
  3. Dopamine receptors in human embryonic stem cell neurodifferentiation.
    Authors: Belinsky Et al.
    Stem Cells Dev  2013;22:1522
  4. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism.
    Authors: Billes Et al.
    Mol Metab  2012;1:86

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