Catalog Number: 1003
Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Biological Activity
A potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    340.85
  • Formula:
    C20H21ClN2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    81226-60-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
    Bowery et al.
    Br.J.Pharmacol., 1996;119:1491
  2. S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
    Millan et al.
    J.Pharmacol.Exp.Ther., 2000;293:1063
  3. Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 r
    Pillai et al.
    Neuropharmacology, 1998;37:983
  4. 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
    Kulagowski et al.
    J.Med.Chem., 1996;39:1941
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-741,626 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors
    Authors: Newton Et al.
    PLoS One 2016;11:e0158808
  2. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    J Neurosci 2015;11:2057
  3. Dopamine receptors in human embryonic stem cell neurodifferentiation.
    Authors: Belinsky Et al.
    Stem Cells Dev 2013;22:1522
  4. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism.
    Authors: Billes Et al.
    Mol Metab 2012;1:86

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