L-741,742 hydrochloride

Key Product Details

Product Description

L-741,742 hydrochloride is a potent and highly selective D₄ dopamine receptor antagonist, with K_i values of > 1700, 770 and 3.5 nM at cloned human D₂, D₃ and D₄ receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-741,742 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-741,742 hydrochloride

The following data is based on the product molecular weight 417.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.96 mL	119.79 mL	239.59 mL
0.5 mM	4.79 mL	23.96 mL	47.92 mL
1 mM	2.40 mL	11.98 mL	23.96 mL
5 mM	0.48 mL	2.40 mL	4.79 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

• Rowley 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D₄ receptor. J.Med.Chem. 1997 PMID: 9240352
• Rowley 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D₄ receptors. J. Med. Chem. 1996 PMID: 8642551

Product Documents for L-741,742 hydrochloride