L-748,337

Key Product Details

Product Description

L-748,337 is a competitive β₃-adrenoceptor antagonist that displays selectivity over β₁ and β₂ receptors (K_i values are 4.0, 204 and 390 nM for β₃-, β₂- and β₁-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC₅₀ = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.

Product Specifications for L-748,337

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-748,337

The following data is based on the product molecular weight 497.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.05 mL	20.10 mL
5 mM	0.40 mL	2.01 mL	4.02 mL
10 mM	0.20 mL	1.00 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Neidhold The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol. 2007 PMID: 17179950
• Dal Monte β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol. 2014 PMID: 24599317
• Candelore Potent and selective human β₃-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10411574

Product Documents for L-748,337