L 760735

Catalog # Availability Size / Price Qty
4013/10
4013/50
L 760735 | CAS No. 188923-01-5 | NK1 Receptor Antagonists
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Description: High affinity NK1 antagonist

Chemical Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

High affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.

Technical Data

M.Wt:
611.98
Formula:
C26H28F7N5O2.HCl
Solubility:
Soluble to 30 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
188923-01-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for L 760735

The citations listed below are publications that use Tocris products. Selected citations for L 760735 include:

1 Citation: Showing 1 - 1

  1. Crystal structure of the human NK1 tachykinin receptor.
    Authors: Yin Et al.
    Proc.Natl.Acad.Sci.U.S.A.  2018;115:13264

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