High affinity NK1
receptor antagonist (IC50
= 0.19 nM at human NK1
receptors). Selective (>300-fold) over h-NK2
receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
Duffy et al.
An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.
Harrison et al.