L 760735

Tocris Bioscience | Catalog # 4013

High affinity NK1 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity NK1 antagonist
View all NK1 Receptor Antagonists »

Product Description

L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.

Product Specifications for L 760735

Molecular Weight

611.98

Formula

C26H28F7N5O2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride

CAS Number

188923-01-5

PubChem ID

9809076

InChI Key

VZBKOBSSEVXFNF-QIRDZIKRSA-N

SMILES

FC(C=C3)=CC=[C@@]3[C@@H]1N(CC4=C(CN(C)C)NN=N4)CCO[C@@H]1O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.36 30
DMSO 30.6 50

Preparing Stock Solutions for L 760735

The following data is based on the product molecular weight 611.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.27 mL 16.34 mL 32.68 mL
2.5 mM 0.65 mL 3.27 mL 6.54 mL
5 mM 0.33 mL 1.63 mL 3.27 mL
25 mM 0.07 mL 0.33 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for L 760735

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L 760735

For research use only

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