Chemical Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
Biological ActivityHigh affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
Duffy et al.
An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.
Harrison et al.
Citation for L 760735
The citations listed below are publications that use Tocris products. Selected citations for L 760735 include:
1 Citation: Showing 1 - 1
Crystal structure of the human NK1 tachykinin receptor.
Authors: Yin Et al.
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VersaClone cDNA Plasmids
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