L-838,417

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L-838,417 | CAS No. 286456-42-6 | GABA-A Receptor Agonists
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Description: GABAA partial agonist; displays subtype selectivity

Chemical Name: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

Technical Data

M.Wt:
399.4
Formula:
C19H19F2N7O
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol with sonication
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
286456-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Product Datasheets

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Citations for L-838,417

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3 Citations: Showing 1 - 3

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