L-838,417

  ( 1 citations )    
Product Datasheet
Catalog Number:3250
Chemical Name:3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
Product Details
Citations (1)
Reviews
Biological Activity
Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.
Technical Data
  • M.Wt:
    399.4
  • Formula:
    C19H19F2N7O
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in ethanol with sonication
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    286456-42-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-838,417 include:

1 Citations: Showing 1 - 1

  1. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.
    Authors: Gee Et al.
    J Pharmacol Exp Ther  2010;332:1040

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used L-838,417?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee