Catalog Number: 3250
Chemical Name: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
Biological Activity
Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.
Technical Data
  • M.Wt:
    399.4
  • Formula:
    C19H19F2N7O
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in ethanol with sonication
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    286456-42-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)
Background References
  1. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour.
    McCabe et al.
    Neuropharmacology, 2004;46:171
  2. Differential behavioural effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys.
    McMahon and France
    Br.J.Pharmacol., 2006;147:260
  3. Reversal of pathological pain through specific spinal GABAA receptor subtypes.
    Knabl et al.
    Nature, 2008;451:330

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