L-NAME hydrochloride

  ( 17 citations )    
Product Datasheet
Catalog Number:0665
Chemical Name:NG-Nitro-L-arginine methyl ester hydrochloride
Product Details
Citations (17)
Reviews
Biological Activity
NO synthase inhibitor.
Technical Data
  • M.Wt:
    269.69
  • Formula:
    C7H15N5O4.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    51298-62-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:

17 Citations: Showing 1 - 10
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  1. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  2. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Proc Natl Acad Sci U S A  2015;35:5664
  3. Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab  2014;34:1128
  4. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res  2014;101:220
  5. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.
    Authors: Elks Et al.
    PLoS Pathog  2013;9:e1003789
  6. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology  2013;67:476
  7. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol  2013;59:20
  8. Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
    Authors: Townsend and Emala
    Am J Physiol Lung Cell Mol Physiol  2013;305:L396
  9. Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus.
    Authors: Vaish and Singh
    Br J Cancer  2013;2013:312146
  10. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci  2011;31:6947
  11. Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.
    Authors: Dai Et al.
    Am J Physiol Heart Circ Physiol  2011;301:H1248
  12. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Authors: Sunters Et al.
    J Biol Chem  2010;285:8743
  13. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  14. Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation.
    Authors: Lou Et al.
    Exp Biol Med (Maywood)  2009;234:1374
  15. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron  2008;57:746
  16. Endocannabinoids control the induction of cerebellar LTD.
    Authors: Safo and Regehr
    Neuron  2005;48:647
  17. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Int J Microbiol  2000;97:11593
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