Catalog Number: 0665
Chemical Name: NG-Nitro-L-arginine methyl ester hydrochloride
Biological Activity
NO synthase inhibitor.
Technical Data
  • M.Wt:
    269.69
  • Formula:
    C7H15N5O4.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    51298-62-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
    Moore and Handy
    TiPS, 1997;18:204
  2. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine.
    Pfeiffer et al.
    Br.J.Pharmacol., 1996;118:1433
  3. Nitric oxide synthases in mammals.
    Knowles et al.
    Biochem.J., 1994;298:249
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:

14 Citations: Showing 1 - 10
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  1. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Proc Natl Acad Sci U S A 2015;35:5664
  2. Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab 2014;34:1128
  3. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res 2014;101:220
  4. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.
    Authors: Elks Et al.
    PLoS Pathog 2013;9:e1003789
  5. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology 2013;67:476
  6. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol 2013;59:20
  7. Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus.
    Authors: Vaish and Singh
    Br J Cancer 2013;2013:312146
  8. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci 2011;31:6947
  9. Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.
    Authors: Dai Et al.
    Am J Physiol Heart Circ Physiol 2011;301:H1248
  10. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Authors: Sunters Et al.
    J Biol Chem 2010;285:8743
  11. Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation.
    Authors: Lou Et al.
    Exp Biol Med (Maywood) 2009;234:1374
  12. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron 2008;57:746
  13. Endocannabinoids control the induction of cerebellar LTD.
    Authors: Safo and Regehr
    Neuron 2005;48:647
  14. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Int J Microbiol 2000;97:11593
Expand to show all 14 Citations

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