Catalog Number: 0771
Chemical Name: NG-Monomethyl-L-arginine acetate
Biological Activity
Competitive, irreversible inhibitor of all three NOS isoforms.
Technical Data
  • M.Wt:
    248.28
  • Formula:
    C7H16N4O2.CH3CO2H
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    53308-83-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases.
    Reif and McCreedy et al.
    Arch.Biochem.Biophys., 1995;320:170
  2. Identification of arginine as a precursor of endothelium-derived relaxing factor.
    Saksuma et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:8664
  3. Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine.
    Olken et al.
    Biochem.Biophys.Res.Commun., 1991;177:828
  4. Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro.
    Rees et al.
    Br.J.Pharmacol., 1990;101:746
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-NMMA acetate include:

2 Citations: Showing 1 - 2
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  1. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently.
    Authors: Schophuizen Et al.
    J Neurosci 2015;4:234
  2. Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity.
    Authors: Echeverría Et al.
    PLoS One 2014;9:e94146

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