Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50
~ 0.1 μ
M); blocks Ca2+
currents in dorsal root ganglion neurons. Analgesic in vivo
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The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons.
Himmel et al.
Arginine-rich peptides are blockers of VR-1 channels with analgesic activity.
Planells-Cases et al.
FEBS Lett., 2000;481:131