L-R₄W₂

Name: L-R 4 W 2
Brand: Tocris Bioscience
SKU: 1577

Tocris Bioscience | Catalog # 1577

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Product Documents

TRPV1 antagonist peptide

Discontinued Product

1577 has been discontinued. View all TRPV Antagonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

TRPV1 antagonist peptide

View all TRPV Antagonists »

Product Description

L-R₄W₂ is a vanilloid TRPV1 (VR1) receptor antagonist peptide (IC₅₀ ~ 0.1 μM); blocks Ca²⁺ currents in dorsal root ganglion neurons. Analgesic in vivo.

Product Specifications for L-R₄W₂

Molecular Weight

1014.20

Formula

C₄₆H₇₁N₂₁O₆

Storage

Desiccate at -20°C

CAS Number

206350-79-0

PubChem ID

90479804

InChI Key

MGQHBRDQUJRCLN-UJARKJSPSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Planells-Cases Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 2000 PMID: 10996311
Himmel The arginine-rich hexapeptide R₄W₂ is a stereoselective antagonist at the vanilloid receptor 1: a Ca²⁺ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 2002 PMID: 12023528

Product Documents for L-R₄W₂

Certificate of Analysis

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Product Specific Notices for L-R₄W₂

For research use only

Related Research Areas

Ion Channels and Regulators

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