Catalog Number: 5045
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Biological Activity
p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
    Yang et al.
    Mol.Cancer Ther., 2013;12:610

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