Catalog Number: 2267
Chemical Name: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
Biological Activity
A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).
Technical Data
  • M.Wt:
    376.42
  • Formula:
    C15H24N2O7S
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    133343-34-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
    Omura et al.
    J.Antibiot., 1991;44:113
  2. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.
    Fenteany et al.
    Science, 1995;268:726
  3. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes.
    Bellas et al.
    Am.J.Pathol., 1997;151:891
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Lactacystin include:

2 Citations: Showing 1 - 2
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  1. FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
    Authors: Wen Et al.
    PLoS One 2015;10:e0135591
  2. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory.
    Authors: Ren Et al.
    Neuropsychopharmacology 2013;38:778

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