Lactacystin

  ( 4 citations )    
Product Datasheet
Catalog Number:2267
Chemical Name:(2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
Product Details
Citations (4)
Reviews
Biological Activity
A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).
Technical Data
  • M.Wt:
    376.42
  • Formula:
    C15H24N2O7S
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    133343-34-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Lactacystin include:

4 Citations: Showing 1 - 4
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  1. FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
    Authors: Wen Et al.
    PLoS One  2015;10:e0135591
  2. Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects.
    Authors: Pandya Et al.
    Psychoneuroendocrinology  2014;45:108
  3. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory.
    Authors: Ren Et al.
    Neuropsychopharmacology  2013;38:778
  4. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097

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