Chemical Name: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
Biological ActivityLactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
Omura et al.
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.
Fenteany et al.
Inhibition of NF-κB activity induces apoptosis in murine hepatocytes.
Bellas et al.
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To tested the effects of inhibiting the proteolytic activity of the 26S proteasome complex via bath application of MG132 (50 M, 4 h) or lactacystin (10 M, 4 h) versus DMSO vehicle control.