A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κ
B activation (IC50
= 10 μ
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Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
Omura et al.
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.
Fenteany et al.
Inhibition of NF-κB activity induces apoptosis in murine hepatocytes.
Bellas et al.
The citations listed below are publications that use Tocris products. Selected citations for Lactacystin include:
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