Lactacystin

Catalog # Availability Size / Price Qty
2267/200U
Lactacystin | CAS No. 133343-34-7 | Proteasome Inhibitors
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Description: Cell-permeable, potent and selective proteasome inhibitor

Chemical Name: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester

Product Details
Citations (6)
Reviews

Biological Activity

A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).

Technical Data

M.Wt:
376.42
Formula:
C15H24N2O7S
Solubility:
Soluble to 10 mM in water
Storage:
Desiccate at -20°C
CAS No:
133343-34-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Lactacystin

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6 Citations: Showing 1 - 6

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