LAIR1 Antibody

Novus Biologicals | Catalog # NBP1-52010

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all LAIR1 Primary Antibodies »

Product Specifications

Immunogen

internal region

Epitope

C-NDTEDVSQASPSE

Reactivity Notes

Cross reacts with Human.

Specificity

This antibody is expected to recognize both isoforms (NP_002278.1; NP_068352.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for LAIR1 Antibody

Western Blot: LAIR1 Antibody [NBP1-52010]

Western Blot: LAIR1 Antibody [NBP1-52010]

Western Blot: LAIR1 Antibody [NBP1-52010] - (2ug/ml) staining of Human Lymph Node lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for LAIR1 Antibody

Application
Recommended Usage

Peptide ELISA

detection limit 1:1000

Western Blot

1-3 ug/ml
Application Notes
This antibody works in ELISA and Western Blot. Approx 28kDa band observed in Human Lymph Node lysates (calculated MW of 29.8kDa according to NP_068352.1). Recommended concentration: 1-3ug/ml.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: LAIR1

CD305 or Leukocyte-associated Ig-like receptor-1 (LAIR-1) is a 46 kD cell surface molecule that functions as an inhibitory collagen-receptor on the majority of cells of the immune system. The mouse LAIR-1 molecule is expressed primarily on monocytes/macrophages and also on T cells, NK cells and dendritic cells. Unlike human B cells, mouse B cells do not express LAIR-1. The cytoplasmic tail of mouse LAIR-1 can be phosphorylated leading to the recruitment of SH2-containing tyrosine phosphatase(SHP)-2 and C-terminal Src kinase.

Long Name

Leukocyte-associated Ig-like Receptor 1

Alternate Names

CD305, HLAIR1, LAIR-1

Entrez Gene IDs

3903 (Human)

Gene Symbol

LAIR1

UniProt

NP_002278.1 (Human)

Additional LAIR1 Products

Product Documents for LAIR1 Antibody

Certificate of Analysis

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Product Specific Notices for LAIR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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