Lalistat 1

Catalog # Availability Size / Price Qty
6098/10
6098/50
Lalistat 1 | CAS No. 501104-16-1 | Lysosomal Acid Lipase Inhibitors
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Description: Potent and selective LAL inhibitor

Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

Technical Data

M.Wt:
298.36
Formula:
C12H18N4O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
501104-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Lalistat 1

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use of lalistat to induce apoptosis
By Anonymous on 09/24/2019
Application: Species: Mouse

Used to inhibit IAP proteins to activate apoptosis


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