Catalog Number: 6098
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
Biological Activity
Potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.
Technical Data
  • M.Wt:
    298.36
  • Formula:
    C12H18N4O3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    501104-16-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
    Rosenbaum et al.
    Biochim.Biophys.Acta., 2009;1791:1155
  2. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.
    Ouimet et al.
    Cell Metab., 2011;13:655
  3. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
    Rosenbaum et al.
    J.Med.Chem., 2010;53:5281
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