Lalistat 2
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity: ≥98%
Biological Activity
Lalistat 2 is a selective lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
Rosenbaum et al.
Biochim.Biophys.Acta., 2009;1791:1155 -
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
Rosenbaum et al.
J.Med.Chem., 2010;53:5281 -
A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2.
Hamilton et al.
Clin.Chim.Acta., 2012;413:1207
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