Catalog Number: 2289
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
Biological Activity
Water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Neurochemical and behavioral aspects of lamotrigine.
    Leach et al.
    Epilepsia, 1991;32:S4
  2. Cardioprotective effect of lamotrigine after focal ischemia in rats.
    Smith and Meldrum
    Stroke, 1995;26:117
  3. Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.
    Zona and Avoli
    Epilepsia, 1997;38:522
  4. Modulation of calcium and potassium currents by lamotrigine.
    Grunze et al.
    Neuropsychobiology, 1998;38:131
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