Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+
currents. Also blocks heterologously expressed and native α
2 nAChRs with a similar affinity to Na+
channels. Water-soluble salt available (lamotrigine isethionate
, Cat. No. 2289).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
Other Product-Specific Information:
Neurochemical and behavioral aspects of lamotrigine.
Leach et al.
Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.
Zona and Avoli
Modulation of calcium and potassium currents by lamotrigine.
Grunze et al.
The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors.
Zheng et al.
The citations listed below are publications that use Tocris products. Selected citations for Lamotrigine include:
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