Lamotrigine

Key Product Details

Product Description

Lamotrigine is an anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na⁺, K⁺ and Ca²⁺ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na⁺ channels.

Water-soluble Salt also available.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for Lamotrigine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lamotrigine

The following data is based on the product molecular weight 256.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.90 mL	19.52 mL	39.05 mL
5 mM	0.78 mL	3.90 mL	7.81 mL
10 mM	0.39 mL	1.95 mL	3.90 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Zona and Avoli Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 1997 PMID: 9184596
• Leach Neurochemical and behavioral aspects of lamotr. Epilepsia 1991 PMID: 1685439
• Zheng The anticonvulsive drug lamotr. blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2010 PMID: 20688974
• Grunze Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 1998 PMID: 9778600

Product Documents for Lamotrigine