Catalog Number: 1611
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Biological Activity
Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble salt available (lamotrigine isethionate, Cat. No. 2289).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Other Product-Specific Information:
Background References
  1. Neurochemical and behavioral aspects of lamotrigine.
    Leach et al.
    Epilepsia, 1991;32:S4
  2. Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.
    Zona and Avoli
    Epilepsia, 1997;38:522
  3. Modulation of calcium and potassium currents by lamotrigine.
    Grunze et al.
    Neuropsychobiology, 1998;38:131
  4. The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors.
    Zheng et al.
    J.Pharmacol.Exp.Ther., 2010;335:401

The citations listed below are publications that use Tocris products. Selected citations for Lamotrigine include:

Showing Results 1 - 1 of 1

  1. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
    Authors: Kashyap Et al.
    J Neurosci
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