Catalog Number: 2582
Alternate Names: AG-1749
Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
Biological Activity
H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).
Technical Data
  • M.Wt:
    369.36
  • Formula:
    C16H14F3N3O2S
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    103577-45-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.
    Satoh et al.
    J.Pharmacol.Exp.Ther., 1989;248:806
  2. The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.
    Schmarda et al.
    Br.J.Pharmacol., 2000;129:598
  3. Lansoprazole.
    Matheson and Jarvis
    Drugs, 2001;61:1801

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