Catalog Number: 2583
Chemical Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Biological Activity
H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.
    Schmarda et al.
    Br.J.Pharmacol., 2000;129:598
  2. Proton pump inhibitors.
    Richardson et al.
    Drugs, 1998;56:307
  3. Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.
    Satoh et al.
    J.Pharmacol.Exp.Ther., 1989;248:806
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