Omeprazole

Biological Activity

Omeprazole is a H⁺,K⁺-ATPase inhibitor (IC₅₀ = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC₅₀ = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (K_i values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.
   Schmarda et al.
   Br.J.Pharmacol., 2000;129:598
2. Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.
   Satoh et al.
   J.Pharmacol.Exp.Ther., 1989;248:806
3. Proton pump inhibitors.
   Richardson et al.
   Drugs, 1998;56:307
4. SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
   Bojkova et al.
   BioRxiv - Paper not yet peer reviewed., 2020;

Product Datasheets