Chemical Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Biological ActivityH+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.
Schmarda et al.
Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.
Satoh et al.
Proton pump inhibitors.
Richardson et al.
SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
Bojkova et al.
BioRxiv - Paper not yet peer reviewed., 2020;
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We use it in the pharmacology lab for the assigment experiments