Lauryl-LF 11
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Description: Analog of LF 11 (Cat. No. 4421); antibiotic
Biological Activity
N-terminally acylated analog of LF 11 (Cat. No. 4421). Displays enhanced antibacterial and LPS-binding activities.Technical Data
M.Wt:
1712.11
Formula:
C81H134N26O15
Sequence:
FQWQRNIRKVR
(Modifications: Phe-1 = CH3-(CH2)10-CO-NH-Phe, Arg-11 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in 30% acetonitrile / water
Storage:
Store at -20°C
CAS No:
832729-14-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity.
Zweytick et al.
Biochim.Biophys.Acta, 2006;1758:1426 -
Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides.
Rosenfeld et al.
Biochemistry, 2010;49:853 -
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide.
Andra et al.
Biochem.J., 2005;385:135
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