Biological ActivityPeptide based on the lipopolysaccharide (LPS)-binding region of human lactoferricin. Neutralizes LPS; displays antimicrobial activity against Gram-negative and Gram-positive bacteria. Analog lauryl-LF 11 (Cat. No. 4422) available.
(Modifications: Arg-11 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide.
Andra et al.
Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides.
Sanchez-Gomez et al.
BMC Mirobiol., 2008;11:196
Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide.
Japelj et al.
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Highly resistant E.Coli produced through gene transfer were subjected to LF 11 and few other antibiotics to assess the antimicrobial activity over the resistant strains.The percentage inhibition over time was determined by disc diffusion and broth dilution methods.