LCB 03-0110 dihydrochloride
Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity: ≥98%
Biological Activity
Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.
Sun et al.
J.Pharmacol.Exp.Ther., 2012;340:510
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Citations for LCB 03-0110 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LCB 03-0110 dihydrochloride include:
2 Citations: Showing 1 - 2
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Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration.
Authors: Fowler Et al.
Drugs R D 2019;19:149
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Collagen Type 1 accelerates healing of ruptured fetal membranes.
Authors: Mogami
Sci Rep 2018;8(1):696
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