LCB 03-0110 dihydrochloride
Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity: ≥98%
Biological Activity
Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.
Sun et al.
J.Pharmacol.Exp.Ther., 2012;340:510
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for LCB 03-0110 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LCB 03-0110 dihydrochloride include:
1 Citation: Showing 1 - 1
-
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Authors: Mogami
Sci Rep 2018;8(1):696
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for LCB 03-0110 dihydrochloride
There are currently no reviews for this product. Be the first to review LCB 03-0110 dihydrochloride and earn rewards!
Have you used LCB 03-0110 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
