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Catalog Number:5592
Chemical Name:3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
Technical Data
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M.Wt:490.45
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Formula:C24H23N3O2S.2HCl
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Solubility:Soluble to 100 mM in water and to 100 mM in DMSO
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Purity:>98
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Storage:Desiccate at RT
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:
The citations listed below are publications that use Tocris products. Selected citations for LCB 03-0110 dihydrochloride include:
1 Citations: Showing 1 - 1
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VersaClone cDNA Plasmids
Description
Application
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Human BTK (NP_000052) VersaClone cDNA
RDC1707
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