LCB 03-0110 dihydrochloride

Tocris Bioscience | Catalog # 5592

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Tocris Bioscience

Key Product Details

Description

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
View all Src Family Kinase Inhibitors »

Product Description

LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Product Specifications for LCB 03-0110 dihydrochloride

Molecular Weight

490.45

Formula

C24H23N3O2S.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride

CAS Number

1962928-28-4

PubChem ID

121513872

InChI Key

OEWGAUGZPPUIPF-UHFFFAOYSA-N

SMILES

OC1=CC=CC(NC2=CC=NC3=C2SC(C4=CC=CC(CN5CCOCC5)=C4)=C3)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 49.05 100
DMSO 49.05 100

Preparing Stock Solutions for LCB 03-0110 dihydrochloride

The following data is based on the product molecular weight 490.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.20 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for LCB 03-0110 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LCB 03-0110 dihydrochloride

For research use only

Citations for LCB 03-0110 dihydrochloride

Customer Reviews for LCB 03-0110 dihydrochloride (1)

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  • Collagen type 1 activated collagen receptor discoidin domain receptor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: 3D Culture Matrix
    Verified Customer | Posted 02/21/2020
    10 μg/ml treat 24h and 48h
    LCB 03-0110 dihydrochloride 5592

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