LCB 03-0110 dihydrochloride

Catalog # Availability Size / Price Qty
5592/10
5592/50
Cat.No. 5592 - LCB 03-0110 dihydrochloride | C24H23N3O2S.2HCl
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Description: Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Technical Data

M.Wt:
490.45
Formula:
C24H23N3O2S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for LCB 03-0110 dihydrochloride

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