LCB 03-0110 dihydrochloride
Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Biological ActivityLCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
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LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.
Sun et al.
Citations for LCB 03-0110 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LCB 03-0110 dihydrochloride include:
2 Citations: Showing 1 - 2
Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration.
Authors: Fowler Et al.
Drugs R D 2019;19:149
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Sci Rep 2018;8(1):696
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