LDN 57444

Catalog # Availability Size / Price Qty
3998/10
3998/50
LDN 57444 | CAS No. 668467-91-2 | Hydrolase Inhibitors
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Description: Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor

Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.

Technical Data

M.Wt:
397.64
Formula:
C17H11Cl3N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
668467-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for LDN 57444

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