Catalog Number: 3998
Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
Biological Activity
Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
    Liu et al.
    Chem.Biol., 2003;10:837
  2. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor.
    Tan et al.
    Mol.Cell.Biochem., 2008;318:109
  3. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
    Cartier et al.
    J.Neurosci., 2009;29:7857
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