LDN 57444

Tocris Bioscience | Catalog # 3998

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor
Tocris Bioscience
Discontinued Product
3998 has been discontinued. View all Hydrolase Inhibitors products.

Key Product Details

Description

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor
View all Hydrolase Inhibitors »

Product Description

LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.

Product Specifications for LDN 57444

Molecular Weight

397.64

Formula

C17H11Cl3N2O3

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

CAS Number

668467-91-2

PubChem ID

24906255

InChI Key

OPQRFPHLZZPCCH-UHFFFAOYSA-N

SMILES

ClC1=CC=C(N(CC3=CC(Cl)=CC=C3Cl)C(C2=NOC(C)=O)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.88 50

Preparing Stock Solutions for LDN 57444

The following data is based on the product molecular weight 397.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.03 mL 25.15 mL 50.30 mL
2.5 mM 1.01 mL 5.03 mL 10.06 mL
5 mM 0.50 mL 2.51 mL 5.03 mL
25 mM 0.10 mL 0.50 mL 1.01 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

Product Documents for LDN 57444

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LDN 57444

For research use only

Customer Reviews for LDN 57444 (1)

4 out of 5
1 Customer Rating
5 Stars
0%
4 Stars
100%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used LDN 57444?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Culture with LDN57444
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Fibroblasts
    Verified Customer | Posted 12/10/2019
    Basal oxygen consumption rates were collected for 4 hours following the addition of CuCl2, LDN57444
    LDN 57444 3998

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All