Biological Activity Inhibitor of dihydroorotate dehydrogenase (IC50 = 2.5 μM). Inhibits de novo pyrimidine synthesis in human T cells in vitro; also inhibits lymphocyte proliferation. Exhibits efficacy in several animal models of autoimmune disease, arthritis and graft rejection. Active metabolite, teriflunomide (A77 1726, Cat. No. 5069), also available.
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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