Leflunomide

  ( 1 citations )    
Product Datasheet
Catalog Number:2228
Alternate Names:HWA 486, RS-34821
Chemical Name:5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Product Details
Citations (1)
Reviews
Biological Activity
Inhibitor of dihydroorotate dehydrogenase (IC50 = 2.5 μM). Inhibits de novo pyrimidine synthesis in human T cells in vitro; also inhibits lymphocyte proliferation. Exhibits efficacy in several animal models of autoimmune disease, arthritis and graft rejection. Active metabolite, teriflunomide (A77 1726, Cat. No. 5069), also available.
Technical Data
  • M.Wt:
    270.21
  • Formula:
    C12H9F3N2O2
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    75706-12-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Leflunomide include:

1 Citations: Showing 1 - 1

  1. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
    Authors: Risse Et al.
    J Biomol Res Ther  2011;300:L958

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