Leflunomide
Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Purity: ≥99%
Biological Activity
Inhibitor of dihydroorotate dehydrogenase (IC50 = 2.5 μM). Inhibits de novo pyrimidine synthesis in human T cells in vitro; also inhibits lymphocyte proliferation. Exhibits efficacy in several animal models of autoimmune disease, arthritis and graft rejection. Active metabolite, teriflunomide (A77 1726, Cat. No. 5069), also available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflun.
Greene et al.
Biochem.Pharmacol., 1995;50:861 -
The immunosuppressant leflun. inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.
Cherwinski et al.
J.Pharmacol.Exp.Ther., 1995;275:1043 -
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacro. (FK506), siro. (rapamycin), mycophen. mofetil and leflun.
Brazelton and Morris
Curr.Opin.Immunol., 1996;8:710
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Citation for Leflunomide
The citations listed below are publications that use Tocris products. Selected citations for Leflunomide include:
1 Citation: Showing 1 - 1
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Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
Authors: Risse Et al.
J Biomol Res Ther 2011;300:L958
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