LEI 101 hydrochloride

Catalog # Availability Size / Price Qty
5826/10
LEI 101 hydrochloride | CAS No. 2250025-91-1 | Cannabinoid R2/CB2 Agonists
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Description: Potent and selective CB2 partial agonist; orally biovailable

Chemical Name: 3-Cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-2,4-imidazolidinedione hydrochloride

Purity: ≥98%

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Biological Activity

Potent and selective CB2 partial agonist (pEC50 = 8.0). Exhibits >100-fold selectivity for CB2 over CB1 and no significant interaction with hFAAH, MAGL, DAGL or NAPE-PLD. Displays antinociceptive activity in a rat neuropathic pain model and attenuates renal inflammation in a mouse kidney damage model. Orally bioavailable with low brain penetration.

Technical Data

M.Wt:
508.99
Formula:
C23H25FN4O4S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2250025-91-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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