Lercanidipine hydrochloride

Tocris Bioscience | Catalog # 2959

CaV1.x blocker
Tocris Bioscience
Discontinued Product
2959 has been discontinued. View all Cav1.x Channel Blockers products.

Key Product Details

Description

CaV1.x blocker
View all Cav1.x Channel Blockers »

Product Description

Lercanidipine hydrochloride is a L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine (Cat. No. 2960). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 2.36 μM).

Product Specifications for Lercanidipine hydrochloride

Molecular Weight

648.19

Formula

C36H41N3O6.HCl

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride

CAS Number

132866-11-6

PubChem ID

157917

InChI Key

WMFYOYKPJLRMJI-UHFFFAOYSA-N

SMILES

CC1=C(C(OC(C)(C)CN(C)CCC(C4=CC=CC=C4)C3=CC=CC=C3)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OC)=O)=C(C)N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.82 100
Ethanol 6.48 10

Preparing Stock Solutions for Lercanidipine hydrochloride

The following data is based on the product molecular weight 648.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.54 mL 7.71 mL 15.43 mL
5 mM 0.31 mL 1.54 mL 3.09 mL
10 mM 0.15 mL 0.77 mL 1.54 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for Lercanidipine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lercanidipine hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Lercanidipine hydrochloride

Customer Reviews for Lercanidipine hydrochloride (1)

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  • Lercanidipine measured against other class calcium channel blockers
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/20/2019
    Lercanidipine blocks L-type calcium channels in the smooth muscle cells of blood vessels and the its effectiveness was measured against other class calcium channel blockers.
    Lercanidipine hydrochloride 2959

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