Lestaurtinib

Catalog # Availability Size / Price Qty
3395/1
Lestaurtinib | CAS No. 111358-88-4 | JAK Kinase Inhibitors
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Description: JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
Alternative Names: CEP-701

Chemical Name: (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one

Purity: ≥99%

Product Details
Citations (7)
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Biological Activity

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM, respectively). Also inhibits Aurora kinase A and B (IC50 values are 8.1 and 2.3 nM, respectively) and prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Technical Data

M.Wt:
439.46
Formula:
C26H21N3O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
111358-88-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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