Catalog Number: 2307
Alternate Names: LTB4, 5,12-DiHETE
Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
Biological Activity
Potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50?g/ml)
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Leukotriene B4: an inflammatory mediator in vivo.
    Bray et al.
    Prostaglandins, 1981;22:213
  2. Leukotriene B4 in inflammation.
    Crit.Rev.Immunol., 1990;10:1
  3. Leukotriene B4: metabolism and signal transduction.
    Yokomitso et al.
    Arch.Biochem.Biophys., 2001;385:231
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