Levetiracetam

Catalog # Availability Size / Price Qty
2839/10
2839/50
Levetiracetam | CAS No. 102767-28-2 | Translocation, Exo/Endocytosis Products
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Description: Binds SV2A; antiepileptic
Alternative Names: Keppra, UCB L059

Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide

Purity: ≥99%

Product Details
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Biological Activity

Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange. In a mouse model of Alzheimer's disease, Levetiracetam rescues levels of presynaptic vesicle fusion and neurotransmitter release, reduces Aβ42 and APP levels and decreases deposits of amyloid plaque; in vitro Levetiracetam inhibits Aβ-induced glutamate from astrocytes.

Technical Data

M.Wt:
170.21
Formula:
C8H14N2O2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
102767-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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