Selective inhibitor of casein kinase (CK) 1δ
values are 290 nM, 1.3 μ
M and 2.5 μ
M for CK1δ
); displays no inhibitory activity at CK2. Inhibits CK1δ
-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.
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A small molecule modulates circadian rhythms through phosphorylation of the period protein.
Lee et al.
Agnew Chem.Int.Ed.Engl., 2011;50:10608
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