Home / Casein Kinase 1 Inhibitors / LH 846

LH 846

Catalog #: 4896
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4896/10
4896/50
LH 846 | CAS No. 639052-78-1 | Casein Kinase 1 Inhibitors
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Description: Selective casein kinase 1δ inhibitor

Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Technical Data

M.Wt:
316.81
Formula:
C16H13ClN2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
639052-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small molecule modulates circadian rhythms through phosphorylation of the period protein.
    Lee et al.
    Agnew Chem.Int.Ed.Engl., 2011;50:10608

Product Datasheets

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Reconstitution Calculator

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Citations for LH 846

The citations listed below are publications that use Tocris products. Selected citations for LH 846 include:

3 Citations: Showing 1 - 3

  1. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
    Authors: Greer Et al.
    PLoS One  2017;12:e0170903
  2. Metabolic cycles in yeast share features conserved among circadian rhythms.
    Authors: Causton Et al.
    Curr.Biol.  2015;25:1056
  3. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
    Authors: Zemp Et al.
    J Cell Sci  2014;127:1242

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