Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Biological ActivityLH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule modulates circadian rhythms through phosphorylation of the period protein.
Lee et al.
Agnew Chem.Int.Ed.Engl., 2011;50:10608
Citations for LH 846
The citations listed below are publications that use Tocris products. Selected citations for LH 846 include:
3 Citations: Showing 1 - 3
Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
Authors: Greer Et al.
PLoS One 2017;12:e0170903
Metabolic cycles in yeast share features conserved among circadian rhythms.
Authors: Causton Et al.
CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
Authors: Zemp Et al.
J Cell Sci 2014;127:1242
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