Chemical Name: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Biological ActivityAnasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
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Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats.
Sarraf et al.
Citations for Lidocaine
The citations listed below are publications that use Tocris products. Selected citations for Lidocaine include:
2 Citations: Showing 1 - 2
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium.
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
Authors: Miguel Angel Garcia-Bereguiain Et al.
The Journal of Neuroscience 2016;6:7268
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Bilateral microinjections of lidocaine (100 micrograms/0.5 microliter/side) into prelimbic, but not infralimbic, medial prefrontal cortex blocked cue-induced reinstatement of MDMA (ecstasy)-seeking behavior compared with saline microinjections into the same region. Lidocaine microinjections into either region did not, however, have an effect on food-maintained responding, ruling out a nonspecific disruption of motor performance.