Recombinant Human LKB1/STK11 His Protein

Novus Biologicals | Catalog # NBP2-51959

Novus Biologicals
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Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE
View all LKB1/STK11 Proteins and Enzymes »

Product Specifications

Description

A denatured recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-433 of Human LKB1/STK11

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMEVVDPQ QLGMFTEGEL MSVGMDTFIH RIDSTEVIYQ PRRKRAKLIG KYLMGDLLGE GSYGKVKEVL DSETLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH KNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF CQLIDGLEYL HSQGIVHKDI KPGNLLLTTG GTLKISDLGV AEALHPFAAD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GKGSYAIPGD CGPPLSDLLK GMLEYEPAKR FSIRQIRQHS WFRKKHPPAE APVPIPPSPD TKDRWRSMTV VPYLEDLHGA DEDEDLFDIE DDIIYTQDFT VPGQVPEEEA SHNGQRRGLP KAVCMNGTEA AQLSTKSRAE GRAPNPARKA CSASSKIRRL SACKQQ

Purity

>85%, by SDS-PAGE

Predicted Molecular Mass

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Application Notes

Denatured protein is most likely not the best option for functional studies. It is better suited for Western Blot (WB) or imaging assays.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human LKB1/STK11 His Protein

SDS-PAGE: Recombinant Human LKB1/STK11 His Protein [NBP2-51959]

SDS-PAGE: Recombinant Human LKB1/STK11 His Protein [NBP2-51959]

SDS-Page: Recombinant Human LKB1/STK11 Protein [NBP2-51959] - 15% SDS Page (3 ug)

Formulation, Preparation, and Storage

NBP2-51959
Formulation 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LKB1/STK11

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Long Name

Serine/threonine Protein Kinase LKB1

Alternate Names

PJS, STK11

Gene Symbol

STK11

Additional LKB1/STK11 Products

Product Documents for Recombinant Human LKB1/STK11 His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human LKB1/STK11 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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Associated Pathways

mTOR Signaling Pathway mTOR Signaling Pathway Thumbnail