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LL-K9-3

Catalog #: 7813 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7813/5

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LL-K9-3 | CAS No. 2809353-52-2 | Active Degraders
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Description: Selective HyT-based degrader of the CDK9-cyclin T1 complex

Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide

Purity: ≥98%

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Biological Activity

LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC50 values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.

Technical Data

M.Wt:
683.94
Formula:
C31H49N5O6S3
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2809353-52-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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