SNS 032

Catalog # Availability Size / Price Qty
4075/10
4075/50
Cyclin-dependent Kinase Inhibitors Small Molecule
1 Image
Description: Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
Alternative Names: BMS-387032

Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC50 >1 μM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data

M.Wt:
380.53
Formula:
C17H24N4O2S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
345627-80-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for SNS 032

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