Catalog Number: 4075
Alternate Names: BMS-387032
Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Biological Activity
Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
Technical Data
  • M.Wt:
    380.53
  • Formula:
    C17H24N4O2S2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    345627-80-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent
    Misra et al.
    J.Med.Chem., 2004;47:1719
  2. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.
    Ali et al.
    Neoplasia, 2007;9:370
  3. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
    Conroy et al.
    Cancer Chemother.Pharmacol., 2009;64:723
  4. Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.
    Chen et al.
    Cancer Res., 2010;70:6587
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SNS 032 include:

1 Citations: Showing 1 - 1

  1. Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.
    Authors: Zhang Et al.
    PLoS One 2015;89:4598

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