SNS 032

  ( 1 citations )    
Product Datasheet
Catalog Number:4075
Alternate Names:BMS-387032
Chemical Name:N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Product Details
Citations (1)
Reviews
Biological Activity
Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
Technical Data
  • M.Wt:
    380.53
  • Formula:
    C17H24N4O2S2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    345627-80-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SNS 032 include:

1 Citations: Showing 1 - 1

  1. Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.
    Authors: Zhang Et al.
    PLoS One  2015;89:4598

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