Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Biological ActivityPotent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Ward TA, McHugh PJ, Durant ST.
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell et al.
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